Computational challenges in mixed‐dimensional beam/solid coupling

Computational Challenges in Seismology

Seismology and engineering seismology have been dramatically affected by the emergence of high-performance computing. A recent report by the National Research Council's Committee on Seismology (NRC, 1996) is entirely devoted to surveying the status and potential of high-performance computing activities in this field. Here we summarize several applications and focus on one particular problem, th...

Computational challenges in systems biology

Systems biology is a broad field that incorporates both computational and experimental approaches to provide a system level understanding of biological function. Initial forays into computational systems biology have focused on a variety of biological networks such as protein-protein interaction, signaling, transcription and metabolic networks. In this review we will provide an overview of avai...

Grand challenges in computational physics

Challenges in computational lower bounds

We draw two incomplete, biased maps of challenges in computational complexity lower bounds. Our aim is to put these challenges in perspective, and to present some connections which do not seem widely known. We do not survey existing lower bounds, go through the history, or repeat standard definitions. All of this can be found e.g. in the recent book [Juk12], or in the books and surveys [SY10, L...

Computational challenges in microbiome research

Millions of bacteria make our bodies their home. They help keep us healthy, and disruptions in the normal micro biota are believed to contribute to a number of diseases. Cost-effective sequencing technologies have made it possible to sequence the genomes of human-associated microbial communities, leading to the birth of a new scientific discipline metagenomics. Analyzing the resulting data, how...